The destabilisation of a double-stranded DNA fragment, which results when substitution of a single nucleotide introduces a G · T base pair, is determined from an equilibrium monitored using imino proton resonances in the n.m.r. spectrum in H2O.
S. A. Salisbury and N. N. Anand, J. Chem. Soc., Chem. Commun., 1985, 985 DOI: 10.1039/C39850000985
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