Issue 4, 1984

Studies of pyrazines. Part 8. Pyrolysis of 2-alkoxypyrazines; substituent effects and stereospecificity

Abstract

Twelve 2-alkoxypyrazines (R = Pri, Bus, 1,2-dimethylpropyl, 1,2,2-trimethylpropyl, t-butyl, t-pentyl, 1,1,2-trimethylpropyl, 1,1,2,2-tetramethylpropyl, octyl, neopentyl, ±-erythro- and ±-threo-2-deuterio-1,2-diphenylethyl) have been pyrolysed to elucidate the substituent effects on the rate and stereospecificity of the reaction. Activation parameters (log A and Ea) for the first eight compounds listed were determined. The reaction was accelerated by α-substitution; this was a combination of both polar and steric effects. The stereospecificity of the reaction was high.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1984, 641-646

Studies of pyrazines. Part 8. Pyrolysis of 2-alkoxypyrazines; substituent effects and stereospecificity

T. Konakahara, K. Sato, Y. Takagi and K. Kuwata, J. Chem. Soc., Perkin Trans. 2, 1984, 641 DOI: 10.1039/P29840000641

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