Two-dimensional nuclear magnetic resonance of natural products. Part 4. Investigation of the solution conformation of luliberin by 1H, 13C, and 2D 1H–13C shift correlation nuclear magnetic resonance spectroscopy
Abstract
Two-dimentional 1H–13C shift correlation has been used for an unambiguous assignment of the 1H and 13C resonances of luliberin (LH-RH). From 1H and 13 n.m.r. spectra obtained at various pH value no evidence for any strong intramolecular interaction has been obtained.