Full details of a high yielding synthesis of mevalonic acid lactone (1) which is of particular value in the preparation of 3- and/or 3′-labelled compounds are described. The key step, conversion of 3-hydroxy-3-methylpentane-1,5-dioic acid (3) into 3-hydroxy-3-methylpentane-1,5-dioic anhydride (4) using acetic anhydride, has been fully investigated, and an additional method using acetyl chloride and triethylamine is described.
E. Bardshiri, T. J. Simpson, A. I. Scott and K. Shishido, J. Chem. Soc., Perkin Trans. 1, 1984, 1765 DOI: 10.1039/P19840001765
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