The synthesis of precocene I epoxide, 3,4-epoxy-7-methoxy-2,2-dimethylchroman (8), is described. This compound is the highly reactive metabolite responsible for the biological effects of the precocenes. The syntheses of some other oxygenated derivatives of precocene I, which are themselves possible metabolites, are also described.
R. C. Jennings and A. P. Ottridge, J. Chem. Soc., Perkin Trans. 1, 1984, 1733 DOI: 10.1039/P19840001733
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