Simple method for the synthesis of 5-substituted 2′,5′-anhydro-2′,5′-dideoxy-1-β-D-arabinofuranosyluracils
Abstract
Reaction of 5-substituted 2′,5′-dichloro-2′,5′-dideoxyuridines (1) with methanolic sodium hydroxide under reflux afforded the corresponding 5-substituted 2′,5′-anhydro-2′,5′-dideoxy-1-β-D-arabinofuranosyluracils (2) in high yields.