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Issue 15, 1984
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Stepwise ring closure in penicillin biosynthesis. Intitial β-lactam formation

Abstract

Incubation of a 1 : 1 mixture of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (L,L,D-ACV) and L,L,D-A[3,3-2H2]CV with a cell-free extract of isopenicillin N synthetase from Cephalosporium acremonium results in preferential conversion of the fully protiated substrate into isopenicillin N; alternatively a similar experiment with a 1 : 1 mixture of L,L,D-ACV and L,L,D-AC[3-2H]V gave isopenicillin N without isotopic discrimination between the two substrates.

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Article information


J. Chem. Soc., Chem. Commun., 1984, 984-986
Article type
Paper

Stepwise ring closure in penicillin biosynthesis. Intitial β-lactam formation

J. E. Baldwin, R. M. Adlington, S. E. Moroney, L. D. Field and H. Ting, J. Chem. Soc., Chem. Commun., 1984, 984
DOI: 10.1039/C39840000984

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