Synthesis of L-serine stereospecifically labelled at C-3 with deuterium
Abstract
(2S,3R)-[3-2H1]- and (2S,3S)-[2,3-2H2]-Serines have been synthesised from the corresponding labelled aspartic acids. The synthesis involves a Baeyer-Villiger oxidation in which a migrating primary chiral centre rearranges with retention of stereochemistry.