Necic acid synthons. Part 2. Regioselectivity in the reactions of Z-2-bromomethyl-2-alkenoate esters with selected carbon nucleophiles
Abstract
The preparation of selected (Z)-2-bromomethyl-2-alkenoate esters and their subsequent reaction with acetoacetic ester-derived nucleophiles is described. Both the substrate structure and the solvent system have significant effects on the regioselectivity of these nucleophilic displacements.