Synthesis and biological activity of some fused β-lactam peptidoglycan analogues

Abstract

The derivatives (12), (14), (15), (19), and (22), in which a mono- or di-peptide unit is linked to 6-aminopenicillanic acid, have been prepared according to normal synthetic peptide procedures. The structures of the side chains were chosen by analogy with the D-isoglutamyl-L-lysyl sequence present in the cell-wall peptidoglycan of Staphylococcus species. The antibacterial activities of the derivatives were measured and the results are discussed.