The biosynthesis of both enantiomers of nonactic acid, and of homononactic acid, has been studied using carbon-13 and oxygen-18 labelled acetate and propionate; this has shown the origin of the oxygen atoms in these building blocks and provided mechanistic information about their mode of biosynthesis and incorporation into the macrotetroloides.
D. M. Ashworth and J. A. Robinson, J. Chem. Soc., Chem. Commun., 1983, 1327 DOI: 10.1039/C39830001327
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