Biosynthetic 15N-enrichment and 15N n.m.r. spectra of neosaxitoxin and gonyautoxin-II: application to structure determination
Abstract
Nitrogen-15 enriched samples of two important neurotoxins, neosaxitoxin and gonyautoxin-II, from the red tide-causing organism, Gonyaulax tamarensis, were prepared by feeding of Na15NO3; 15N n.m.r. spectra of the enriched toxins support the structural assignments previously made for these toxins.
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