The mechanism of acid hydrolysis of the microbial antibiotic nocardicin A has been examined by a comparison of its kinetic dependence upon acid concentration with those of several β-lactams and oximes. It is concluded that, in moderately concentrated sulphuric acid, the faster reaction is β-lactam hydrolysis but that the spectral changes are due to hydrolysis of the oxime group.
A. R. Butler, D. I. Robinson and D. E. Wright, J. Chem. Soc., Perkin Trans. 2, 1982, 437 DOI: 10.1039/P29820000437
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