Organocuprate conjugate addition reactions of 2,3-dihydrothiin-4-one, its oxide and dioxide
Abstract
The conjugate-addition reactions between 2,3-dihydrothiin-4-one (2) and a number of copper-containing organometallic reagents are described. New methods have been developed for the synthesis of a variety of 2-substituted thian-4-ones and the corresponding sulphoxides and sulphones. Approaches to the synthesis of 2,3-disubstituted thian-4-ones are also discussed.