Microbiological transformations. Part 5. Microbiological transformations of 17a-aza- and 17-aza-D-homoandrost-5-ene derivatives with the fungus Cunninghamella elegans

Abstract

The products obtained from the incubation of 17a-aza- and 17-aza-D-homoandrost-5-ene derivatives with Cunninghamella elegans are largely those resulting from allylic oxidation or epoxidation of the Δ⁵-bond. The substrates are predominantly monohydroxylated whereas androst-5-ene derivatives under the same conditions show a tendency towards dihydroxylation.