2-Alkylamino-4,6-diphenylpyrimidines are acylated only at nitrogen after treatment with lithium di-isopropylamide (LDA). 4,6-Diaryl-1 -benzylpyrimidin-2(1H)-ones can be acylated and alkylated at the α-CH2 group. 1-Methyl-4,6-di-p-tolylpyrimidin-2(1H)-one forms a carbanion which undergoes dimerisation.
A. R. Katrizky, H. J. Salgado, A. Chermprapai and N. K. Ponkshe, J. Chem. Soc., Perkin Trans. 1, 1982, 153 DOI: 10.1039/P19820000153
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