The selective opening of α,β,-epoxyketone trimethylsilyl enol ethers by cuprate reagents: selectivity reversal in tetrahydrofuran
Abstract
Lithium dialkylcuprates in tetrahydrofuran give direct opening of α,β,-epoxyketone trimethylsilyl enol ethers, in contrast to the allylic opening with cuprates reagents in diethyl ether.