A rapid, stereospecific synthesis of 2-deoxy-2-fluoro-D-glucose using the fluoride ion
Abstract
The reaction of KHF2 with 1,2-anhydro-3,4- : 5,6-di-O-isopropylidene-1-C-nitro-D-mannitol (4) provides a rapid, stereospecific route to 2-deoxy-2-fluoro-D-glucose (2), the 18F-labelled analogue of which, (1), is an important radiopharmaceutical of use in medical imaging.