New routes for the synthesis of estra-1,3,5(10)-triene-2,3,17β-triols-(catechol estrogens)
Abstract
2,3,17β-Tricetoxyestra-1,3,5(10)-triene has been prepared in good yields either from 2-chloromercurio-3-methyl-17β-acetoxyestra-1,3,5(10)-triene by a novel hydroboration–oxidation route or by oxidation of a previously unknown 2-organoboron substituted estradiol.