The flouren-9-ylmethoxycarbonyl group for the protection of hydroxy-groups; its application in the synthesis of an octathymidylic acid fragment

Abstract

The fluoren-9-ylmethoxycarbonyl (Fmoc) group may be used to protect hydroxy-groups in conjunction with a variety of acid- and base-labile protecting groups; the Fmoc group may be conveniently removed by the action of triethylamine (10 equiv.) in dry pyridine solution within 2 h at 20 °C while other base-labile protecting groups remained intact.