Direct iodination of estradiol, estriol, and estrone using iodine–copper(II) acetate in acetic in acid afforded the 2-iodo-derivatives regioselectively in high yield.
C. A. Horiuchi and J. Y. Satoh, J. Chem. Soc., Chem. Commun., 1982, 671 DOI: 10.1039/C39820000671
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