Direct studies of reactions of 17O-labelled cobaloximes by 17O n.m.r. spectroscopy: hydrolysis of 2-acetoxyethyl(pyridine) cobaloxime and hydration of formylmethyl(pyridine) cobaloxime

Abstract

Using ¹⁷O n.m.r. spectroscopy to monitor reactions, the hydrolysis of 2-acetyl[¹⁷O]oxyethyl(pyridine)-cobaloxime is shown to proceed via the B_AL1 mechanism, whilst the hydration of [¹⁷O]formylmethyl(pyridine)- cobaloxime takes place with τ_1/2ca. 19 h in dioxan–aqueous 0.1 mol dm^-3phosphate (pH 6.8)(3:2) at 50°C.