The Readily accessible spirocyclic oxyphosphorane, 2,2′-spirobi(1,3,2-benzodioxaphosphole)(1), is a convenient and effective reagent for peptide coupling, racemisation as measured by the lzumiya test being strikingly suppressed to <0.1% in the presence of N-hydroxysuccinimide.
J. I. G. Cadogan, I. Gosney, D. Randles, S. Yaslak and R. P. Ambler, J. Chem. Soc., Chem. Commun., 1982, 298 DOI: 10.1039/C39820000298
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