Synthesis of (3S)-[3-hydroxy-(E)-prop-1-enyl]cyclopentanone, potential versatile chiral synthon for natural products from(R)-1,2-isopropylideneglyceraldehyde
Abstract
(3S)-[3-Hydrox-(E)-Prop-1-enyl]cyclopentanone (1) has been synthesised from an easily available chiral starting material, (R)-1,2-isopropylideneglyceraldehyde (4) through orthoester Claisen rearrangement of (5) and (7).