Optical rotatory dispersion and absolute configuration. Part 32. Circular dichroism and conformation of 3-hydroxypiperidines
Abstract
C.d. measurements show that a simple piperidine helicity rule gives the correct sign of the Cotton effect for the conformationally rigid (R)-quinuclidin-3-ol. Application of the same helicity rule also supports logical conformations and configurational assignments for (R)-1-methylpiperidin-3-ol and (R)-piperidin-3-ol.