Synthesis of lichesterol [ergosta-5,8(9),22-trien-3β-ol]
Abstract
Ergosta-5,8(9),22-trien-3β-ol has been synthesized and its identity with lichesterol has been confirmed. Ergosteryl acetate was transformed into 7α-[NN′-bis(ethoxycarbonyl)hydrazino]ergosta-5,8(9),22-trien-3β-yl acetate which was converted into lichesterol by reduction with lithium in ethylamine.