A synthesis of adenosine 5′-[β-18O2]triphosphate (8) has been achieved by a novel route in an overall yield of 19% based on phosphorus pentachloride. The use of the diphenylmethyl protecting group is a key feature of the synthesis. Some 18O isotope shifts in 31P and 13C n.m.r. spectra are reported.
G. Lowe and B. S. Sproat, J. Chem. Soc., Perkin Trans. 1, 1981, 1874 DOI: 10.1039/P19810001874
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