Asymmetric induction in the reduction of β-oxosulphoximides by sodium borohydride
Abstract
Optically active β-oxosulphoximides have been prepared by reaction of optically active α-metallated NS-dimethyl-S-phenylsulphoximide with carboxylic esters. Their reduction by sodium borohydride is stereoselective, the extent of asymmetric synthesis (up to 50%) depending on steric factors.