Mode of mammalian oxygenation at primary carbon atoms: steric course of hydroxylation of C-1 chiral octanes by rat liver microsomes

Abstract

It is shown that mammalian microsomal cyto-chrome P₄₅₀ converted C-1 isotopically labelled (1R)- and (1S)-octane into octan-1-ol with retention, whereby the incoming hydroxy-group assumes the same orientation as the displaced hydrogen.