Enantioselective route to both (+)- and (–)-enantiomers of quebrachamine using a single chiral synthon
Abstract
An enantioselective route to both the (+)- and (–)-enantiomers of the Aspidosperma-type indole alkalloid, quebrachamine, has been established using a single chiral lactone obtained from L-glutamic acid or D-mannitol.