Synthesis of nitrosothioureas. 15N N.m.r. evidence for the formation of thionitrosyl compounds in the nitrosation of thioureas
Abstract
Nitrosothioureas may be prepared by treatment of thioureas with NaNO2 in 0·1 N HCl at –5 °C by direct N-nitrosation whereas 15N n.m.r. studies at –10 °C which employed specifically 15N-enriched compounds revealed the intermediacy of a thionitrosyl compound under more acidic conditions which gave the urea by hydrolysis.