Stereocontrolled synthesis of 4-demethoxy-7-O-methyldaunomycinone
Abstract
The Diels–Alder adduct (6), prepared from 4a,9a-epoxy-4a,9a-dihydroanthracene-1,4,9,10-tetraone (3) and 1-methoxy-3-trimethylsilyloxybuta-1,3-diene, can be efficiently converted into the title compound (2b), a precursor of 4-demethoxydaunomycin (1d), by a five-step sequence.