The four possible stereoisomers of a new metabolite of vitamin D3, 25-hydroxycholecalciferol-26, 23-lactone, have been synthesised; we establish that the natural product has the 23R, 25S stereochemistry, and that it has <1% of the activity of vitamin D3 in bringing about intestinal calcium absorption.
D. S. Morris, D. H. Williams and A. F. Norris, J. Chem. Soc., Chem. Commun., 1981, 424 DOI: 10.1039/C39810000424
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