Co-operative effects in the catalytic action of N-decanoyl-L-histidine in micelles

Abstract

A comparison of catalytic effects in the hydrolysis of the enantiomeric esters (2) by N-decanoyl-L-histidine (1a) and its methyl ester (1b) in the presence of cetyltrimethylammonium bromide micelle strongly suggests that the carboxylate ion of (1a) enhances the reactivity of the imidazole group through intramolecular hydrogen-bonding.