Synthetic C-glycosyl nucleosides. A new approach
Abstract
A synthesis of a series of C-nucleoside analogues is described starting from readily available hexulasonic acid derived from fructose. The construction of imidazole-pyridine and -pyrimidine heterocycles under mild conditions is described for five derivatives. 13C N.m.r. analysis of one product shows equilibrium between anomeric furanose and pyranose forms, depending upon the solvent.