The synthesis of 4-ethyl-3,3a,10,11,12,12a-hexahydro-12-methyl-2H-furo[3′,2′:5,6]pyrido[3,4-a]carbazol-2-yl methyl ketone. Structure of subincanine

Abstract

The synthesis of the two 12a,3a-cis-stereoisomers of the title ketone (6b) is described; it is shown that none of the stereoisomers corresponds to subincanine, an alkaloid which had earlier been, preliminarily assigned this structure. The differences between natural alkaloid and synthetic material are discussed.