Conversion of pyridines and quinolines into pyridazines and pyrazoles
Abstract
3-Phenacylpyridinium and 3-phenacylquinolinium methiodides are shown to react with hydrazine–potassium hydroxide and hydrazine respectively to give 4-alkyl-6-phenylpyridazines and 4-(2-aminobenzyl)-6-phenylpyridazines respectively. 3-Benzoylpyridinium methiodide gives 3-phenyl-4-propylpyrazole with hydrazine–potassium hydroxide, then catalytic reduction.