In alkaline solution, 8-carboxamido-2′-O-tosyladenosine (4e; R2= R3= H), which may be prepared from adenosine in 7 steps, readily cyclizes to give (5); in neutral or weakly basic solution, it undergoes virtually quantitative conversion into ara-A (1a).
K. J. Divakar and C. B. Reese, J. Chem. Soc., Chem. Commun., 1980, 1191 DOI: 10.1039/C39800001191
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