Transformation of cephalosporins: preparation of a 3-methyl-3-nitro-4-hydroxyiminocepham
Abstract
The reaction of N2O3 with 3-methyl-7β-phenoxyacetamidoceph-3-em-4-carboxylic acid gives, by an addition–decarboxylation sequence, 3α-methyl-3β-nitro-4(E)-hydroxyimino-7β-phenoxyacetamidocepham-4carboxylic acid.