Analysis of human urine for a metabolite of endrin by chemical oxidation and gas-liquid chromatography as an indicator of exposure to endrin

Abstract

A method for determining residues of the β-glucuronide of anti-12-hydroxyendrin in urine is presented. Samples are treated with sodium metaperiodate followed by mild base hydrolysis. The anti-12-hydroxyendrin is determined by gas-liquid chromatography with electron-capture detection. Chemical confirmation techniques are described. Results obtained from analyses of urine samples from workers at an endrin manufacturing plant are included.