Proton transfer from heterocyclic compounds. Part 9. Effect of transition-metal ion co-ordination on isotopic hydrogen exchange in purines

Abstract

Rates of detritiation from the C-8 position of 1-methyl[8-³H]guanosine and 1-methyl[8-³H]inosine at 85 °C in the presence of various metal ions are reported. Analysis of the data shows that the metal-complexed species are more reactive than the neutral species by factors of 10⁴–10⁶ but less reactive than the protonated substrates. Detritiation studies on the cis[(1,2-diaminoethane)(guanosine)₂]platinum di-iodo-complex are consistent with this viewpoint.