The spontaneous formation of the lactam from the neighbouring amino and carboxy groups of 3-(2-aminophenyl)propionic acid involves general acid catalysed and spontaneous reactions of the neutral amino-acid. The conditions necessary, and the mechanisms involved, suggest that spontaneous amide formation could be biologically significant.
P. Camilleri, R. Ellul, A. J. Kirby and T. G. Mujahid, J. Chem. Soc., Perkin Trans. 2, 1979, 1617 DOI: 10.1039/P29790001617
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