Synthesis of structural analogues of 6,7,8,9-tetrahydro-3-hydroxy-2-methoxybenzocyclohepten-5-one
Abstract
6,7,8,9-Tetrahydro-2-methoxy-3-nitrobenzocyclohepten-5-one has been made, separated from an isomer, and converted into several bromo-compounds, two of which were further studied. 2,3,4,5-Tetra hydro-7-hydroxy-8-methoxy-1-benzazepin-5-one has been obtained in several steps from methyl 4,5-dimethoxyanthranilate for which an improved synthesis has been developed. Preparations of 6-hydroxy-7-methoxynaphthalen-1 (2H)-one and 7-hydroxy-6-methoxynaphthalen-1 (2H)-one have been reinvestigated and an unequivocal synthesis of the latter is presented.