Synthesis of cyclopenta[cd]pyrene 3,4-epoxide, the ultimate mutagenic metabolite of the environmental carcinogen, cyclopenta[cd]pyrene
Abstract
Cyclopenta[cd]pyrene 3,4-epoxide, a potent bacterial mutagen, has been synthesized via the bromohydrin obtained from the addition of hypobromous acid to the ethylenic bridge of cyclopenta[cd]pyrene.