Readily available tetrahydro-1,3-oxazines on acylation with diketen followed by diazo exchange, irradiation, and reduction give 8-oxo-7-(1-hydroxyethyl)-3-oxa-l-azabicyclo[4.2.0]octane derivatives having trans-substituents about the β-lactam ring.
R. J. Ponsford and R. Southgate, J. Chem. Soc., Chem. Commun., 1979, 846 DOI: 10.1039/C39790000846
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