Clavulanic acid (1) is converted by an efficient one-step process into the conjugated diene (3), which has been used in the preparation of novel analogues of (1), such as (4), (6), and (7).
E. Hunt, J. Chem. Soc., Chem. Commun., 1979, 686 DOI: 10.1039/C39790000686
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