Cultures of Claviceps species, strain SD 58, efficiently incorporate N-methyl-4-(γγ-dimethylallyl)-tryptophan (1) as an intact unit into elymoclavine (2), whereas the corresponding tryptamine (3) is not utilized, suggesting N-methylation as the second pathway-specific step in ergot alkloid biosynthesis and rendering pyridoxal phosphate catalysis of C-ring closure unlikely.
H. Otsuka, J. A. Anderson and H. G. Floss, J. Chem. Soc., Chem. Commun., 1979, 660 DOI: 10.1039/C39790000660
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