Oxidation of N-alkylhydroxamic acids: interception of N-acyl nitrones
Abstract
The acyl alkyl nitroxides (2), formed by one-electron oxidation of N-alkylhydroxamic acids, may disproportionate to give the N-acyl nitrones (3); as well as being powerful acylating agents, these transient species can be intercepted by cycloaddition to N-phenylmaleimide, and by ‘spin-trapping’ various radicals, including their nitroxide precursors.