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Issue 0, 1979

Polypeptides. Part 17. Aminoxy-analogues of aspartame and gastrin C-terminal tetrapeptide amide

Abstract

L- and D-2-Aminoxy-3-phenylpropionic acid have been prepared from D- and L-phenylalanine by a route which is generally applicable to other optically active amino-acids. Appropriate methodology enabled incorporation of the L-isomer in place of L-phenylalanine in Asp-Phe-OMe (to provide an aminoxy-analogue which was not sweet) and Trp-Met-Asp-Phe-NH2, (to provide an aminoxy-analogue which did not stimulate gastric acid secretion).

Article information


J. Chem. Soc., Perkin Trans. 1, 1979, 2138-2143
Article type
Paper

Polypeptides. Part 17. Aminoxy-analogues of aspartame and gastrin C-terminal tetrapeptide amide

M. T. Briggs and J. S. Morley, J. Chem. Soc., Perkin Trans. 1, 1979, 2138 DOI: 10.1039/P19790002138

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