Further polyacetylenes from Polyporus anthracophilus: specific incorporation of [1-14C]matricaria esters into polyacetylenic metabolites of this fungus

Abstract

A further eight C₁₀ polyacetylenes have been isolated from cultures of Polyporus anthracophilus. Several of these, notably Z,Z- and 2E,8Z-matricaria ester and Z,Z-matricarianol, have not previously been isolated from fungi. When a mixture of E,E-[1-¹⁴C]matricaria ester and 2E,8Z-[1-¹⁴C]matricaria ester was fed to cultures of P. anthracophilus, one or both of these esters were specifically incorporated into E,E-matricarianol, Z,Z-matricarianol, and dimethyl E,E-deca-2,8-diene-4,6-diyne-1,10-dioate. This provides strong evidence that in this organism, matricaria esters are intermediates in the production of many of the polyacetylenic metabolites.